Zoloft Information

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Sertraline hydrochloride, marketed as Zoloft, is an antidepressant used to treat major depression as well as obsessive-compulsive disorder, post-traumatic stress disorder, and panic and social anxiety issues. Zoloft, which was introduced into the market by Pfizer in 1991, is classified as a selective serotonin reuptake inhibitor (SSRI) antidepressant. SSRI medications are widely prescribed and are used more than any other drug to treat depression in the U.S. Other SSRI medications include Celexa and Lexapro, among others.

The Food and Drug Administration initially placed SSRI antidepressants including Zoloft in its pregnancy “Category C” class of medications. This pregnancy category means that animal reproduction studies have shown an adverse effect on the fetus and there are no adequate well-controlled studies in humans. The Pregnancy categories measure the teratogenic effects a drug has on a fetus. Teratogenic means that a drug or other substance is capable of interfering with the development of a fetus.

​Baby Jennifer had to undergo open-heart surgery before her first birthday. Her mother took Zoloft during her pregnancy with Jennifer, which had been touted as safe to use. Jennifer has spent much of her infant life in and out of hospitals.

Detailed Zoloft Information

Pharmaceutical: Zoloft

Manufacturer: Pfizer

Generic Name: sertraline (or sertraline hydrochloride)

Drug Class: Selective serotonin reuptake inhibitor (SSRI) antidepressant

CAS Number: 79617-96-2

Guidelines:

Zoloft is used to treat the following disorders:

• major depressive disorder (MDD)
• obsessive-compulsive disorder (OCD)
• body dysmorphic disorder (BDD)
• posttraumatic stress disorder (PTSD)
• premenstrual dysphoric disorder (PMDD)
• panic disorder
• and social phobia (social anxiety disorder, or SAD)

Contraindications:

• The use of MAOIs intended to treat psychiatric disorders with Zoloft or within 14 days of stopping treatment with Zoloft is contraindicated because of an increased risk of serotonin syndrome.
• The use of Zoloft within 14 days of stopping an MAOI intended to treat psychiatric disorders is also contraindicated.
• Concomitant use in patients taking pimozide is contraindicated. Zoloft is contraindicated in patients with a hypersensitivity to sertraline or any of the inactive ingredients in Zoloft.